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Hum Mol Genet. 2014 Sep 15;23(R1):R54-63. doi: 10.1093/hmg/ddu207. Epub 2014 May 16.

Natural antisense transcripts.

Author information

1
OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
2
Department of Psychiatry and Behavioral Sciences and.
3
Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA CWahlestedt@med.miami.edu.

Abstract

Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously thought to be 'junk DNA'. Roughly defined as non-coding regulatory RNA transcribed from the opposite strand of a coding gene locus, NATs are proving to be a heterogeneous group with high potential for therapeutic application. Here, we attempt to summarize the rapidly growing knowledge about this important non-coding RNA subclass.

PMID:
24838284
PMCID:
PMC4170719
DOI:
10.1093/hmg/ddu207
[Indexed for MEDLINE]
Free PMC Article

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