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EMBO Mol Med. 2014 Jun;6(6):705-7. doi: 10.15252/emmm.201404179. Epub 2014 Apr 6.

Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?

Author information

1
Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences Medical School Newcastle University, Newcastle upon Tyne, UK.

Abstract

Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al (2014) use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.

PMID:
24838280
PMCID:
PMC4203349
DOI:
10.15252/emmm.201404179
[Indexed for MEDLINE]
Free PMC Article

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