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Gut Microbes. 2014 May-Jun;5(3):404-10. doi: 10.4161/gmic.29232. Epub 2014 May 16.

The effects of gut microbiota on CNS function in humans.

Author information

1
The Oppenheimer Center for Neurobiology of Stress; Division of Digestive Diseases; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.

Abstract

The role of the gastrointestinal microbiota in human brain development and function is an area of increasing interest and research. Preclinical models suggest a role for the microbiota in broad aspects of human health, including mood, cognition, and chronic pain. Early human studies suggest that altering the microbiota with beneficial bacteria, or probiotics, can lead to changes in brain function, as well as subjective reports of mood. As the mechanisms of bidirectional communication between the brain and microbiota are better understood, it is expected that these pathways will be harnessed to provide novel methods to enhance health and treat disease.

KEYWORDS:

anxiety; brain-gut axis; depression; microbiota; probiotic

PMID:
24838095
PMCID:
PMC4153780
DOI:
10.4161/gmic.29232
[Indexed for MEDLINE]
Free PMC Article

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