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Immunity. 2014 May 15;40(5):637-9. doi: 10.1016/j.immuni.2014.04.015.

IL-10 and macrophages orchestrate gut homeostasis.

Author information

1
Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
2
Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy.

Abstract

Macrophages in the gut originate from blood precursors and have distinct functional properties. In this issue of Immunity,Zigmond et al. (2014) and Shouval et al. (2014) report that interleukin-10 drives macrophages to express homeostatic tolerogenic functions, preventing colitis.

PMID:
24837099
DOI:
10.1016/j.immuni.2014.04.015
[Indexed for MEDLINE]
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