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Semin Perinatol. 2014 Apr;38(3):139-45. doi: 10.1053/j.semperi.2014.03.005.

Pathophysiology of ischemic placental disease.

Author information

1
Magee-Womens Research Institute, Pittsburgh, PA 15213; Department of Obstetrics, Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research, University of Pittsburgh, Pittsburgh, PA. Electronic address: jroberts@mwri.magee.edu.

Abstract

The pregnancy disorders associated with placental ischemia share many similar pathological and pathophysiological features and are associated with the failure to deliver adequate nutrients and oxygen to the placenta. The origins of this deficiency are a subject of intense study. In this article, I review the genesis and consequences of this pathology addressing the similarities and the differences with the different disorders and addressing current gaps in our knowledge.

KEYWORDS:

intrauterine growth restriction; placenta; placenta ischemia; preeclampsia; premature birth

PMID:
24836825
PMCID:
PMC4040272
DOI:
10.1053/j.semperi.2014.03.005
[Indexed for MEDLINE]
Free PMC Article

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