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Trends Microbiol. 2014 Jun;22(6):304-6. doi: 10.1016/j.tim.2014.04.011. Epub 2014 May 14.

The target cell genus does not matter.

Author information

1
CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée (IMM), Marseille, France. Electronic address: bleves@imm.cnrs.fr.
2
CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée (IMM), Marseille, France.

Abstract

Two type VI secreted phospholipases D of Pseudomonas aeruginosa were identified as trans-kingdom virulence effectors, targeting both prokaryotic and eukaryotic host cells. Each of them triggers killing bacterial competitors and internalization into non-phagocytic cells. These type VI lipolytic enzymes are widely distributed among pathogens and may constitute a conserved strategy.

PMID:
24836109
DOI:
10.1016/j.tim.2014.04.011
[Indexed for MEDLINE]

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