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Trends Microbiol. 2014 Jun;22(6):306-8. doi: 10.1016/j.tim.2014.04.010. Epub 2014 May 14.

The gut microbiome, probiotics, bile acids axis, and human health.

Author information

1
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
2
Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada. Electronic address: satya.prakash@mcgill.ca.

Abstract

The human gut microbiome produces potent ligands to bile acid receptors, and probiotics could act as therapeutics of bile acid dysmetabolism. A recent study in Cell Reports demonstrates that probiotic VSL#3 affects bile acid deconjugation and excretion, as well as the gut-liver FXR-FGF15 axis.

PMID:
24836108
DOI:
10.1016/j.tim.2014.04.010
[Indexed for MEDLINE]

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