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Comput Biol Med. 2014 Jul;50:70-5. doi: 10.1016/j.compbiomed.2014.04.012. Epub 2014 Apr 28.

The diagnostics of diabetes mellitus based on ensemble modeling and hair/urine element level analysis.

Author information

1
Hospital, Yibin University, Yibin, Sichuan 644007, China.
2
Department of Chemistry and Chemical Engineering and Key Lab of Process Analysis and Control, Yibin University, Yibin, Sichuan, China; Computational Physics Key Laboratory of Sichuan Province, Yibin University, Yibin, Sichuan 644007, China. Electronic address: chaotan1112@163.com.
3
The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
4
Department of Chemistry and Chemical Engineering and Key Lab of Process Analysis and Control, Yibin University, Yibin, Sichuan, China.

Abstract

The aim of the present work focuses on exploring the feasibility of analyzing the relationship between diabetes mellitus and several element levels in hair/urine specimens by chemometrics. A dataset involving 211 specimens and eight element concentrations was used. The control group was divided into three age subsets in order to analyze the influence of age. It was found that the most obvious difference was the effect of age on the level of zinc and iron. The decline of iron concentration with age in hair was exactly consistent with the opposite trend in urine. Principal component analysis (PCA) was used as a tool for a preliminary evaluation of the data. Both ensemble and single support vector machine (SVM) algorithms were used as the classification tools. On average, the accuracy, sensitivity and specificity of ensemble SVM models were 99%, 100%, 99% and 97%, 89%, 99% for hair and urine samples, respectively. The findings indicate that hair samples are superior to urine samples. Even so, it can provide more valuable information for prevention, diagnostics, treatment and research of diabetes by simultaneously analyzing the hair and urine samples.

KEYWORDS:

Diabetes; Diagnosis; Ensemble; Support vector machine; Trace element

[Indexed for MEDLINE]

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