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Angiology. 2015 May;66(5):441-7. doi: 10.1177/0003319714535970. Epub 2014 May 16.

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio combination can predict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

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Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey
Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Department of Cardiology, Marmara University Pendik Research and Training Hospital, Istanbul, Turkey.
Department of Cardiology, Edirne State Hospital, Edirne, Turkey.
Department of Cardiology Istanbul, Siyami Ersek Center for Cardiovascular Surgery, Turkey.
Department of Cardiology, Kadirli State Hospital, Osmaniye, Turkey.
Department of Cardiology, Faculty of Medicine, Bezmi Alem Vakıf University, İstanbul, Turkey.


We assessed the effect of combination of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting in-hospital and long-term mortality in patients (n = 2518) undergoing primary percutaneous coronary intervention (pPCI). Cutoff values for NLR and PLR were calculated with receiver-operating characteristic (ROC) curves. If both PLR and NLR were above the threshold, patients were classified as "high risk." If either PLR or NLR was above the threshold individually, patients were classified as "intermediate risk." High-risk (n = 693) and intermediate-risk (n = 545) groups had higher in-hospital and long-term mortality (7.2 4% vs 0.7%, P < .001; 14.1, 9.5% vs 4.5%, P < .001, respectively). Classifying patients into intermediate-risk group (hazards ratio [HR]: 1.492, 95% confidence interval [CI]: 1.022-2.178, P = .038) and high-risk group (HR: 1.845, 95% CI: 1.313-2.594, P < .001) was an independent predictor of in-hospital and long-term mortality. The combination of PLR and NLR can be useful for the prediction of in-hospital and long-term mortality in patients undergoing pPCI.


acute ST-segment elevation myocardial infarction; neutrophil–lymphocyte ratio; platelet–lymphocyte ratio; primary angioplasty

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