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Cell Host Microbe. 2014 May 14;15(5):523-5. doi: 10.1016/j.chom.2014.05.001.

Endosomes as platforms for NOD-like receptor signaling.

Author information

1
Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02446, USA.
2
Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02446, USA. Electronic address: jonathan.kagan@childrens.harvard.edu.

Abstract

The NOD-like receptors (NLRs) were among the first innate immune receptors discovered, yet a clear understanding of the basic principles underlying their mechanisms of action is lacking. Two recent studies provide important cell biological insights into the subcellular sites of NOD1- and NOD2-dependent signaling.

PMID:
24832447
PMCID:
PMC4067698
DOI:
10.1016/j.chom.2014.05.001
[Indexed for MEDLINE]
Free PMC Article

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