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Curr Opin Biotechnol. 2014 Aug;28:59-68. doi: 10.1016/j.copbio.2013.11.007. Epub 2013 Dec 25.

Biomolecular scaffolds for enhanced signaling and catalytic efficiency.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States.
2
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City, Taiwan.
3
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: wilfred@udel.edu.

Abstract

Proteins inherently are not designed to be standalone entities. Whether it is a multi-step biochemical reaction or a signaling event that triggers several other cascading events, proteins are naturally designed to function cohesively. Several natural systems have been developed through evolution to co-localize the functional proteins of the same pathway in order to ensure efficient communication of signals or intermediates. This review focuses on some selected examples of where synthetic scaffolds inspired by nature have been used to enhance the overall biological pathway performance. Applications encompass both in vivo and in vitro systems that address two key biological events in cell signaling and biosynthesis will be discussed.

PMID:
24832076
DOI:
10.1016/j.copbio.2013.11.007
[Indexed for MEDLINE]

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