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Br J Ophthalmol. 2014 Oct;98(10):1368-73. doi: 10.1136/bjophthalmol-2013-304547. Epub 2014 May 15.

Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis.

Author information

1
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA Affiliated Sixth People's Hospital Shanghai Jiao Tong University, Shanghai, P.R. China.
2
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
3
Department of Neurology, Portland VA Medical Center, Oregon Health & Science University, Portland, Oregon, USA.
4
Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
5
Pattern Recognition Lab and School of Advanced Optical Technologies (SAOT), University Erlangen-Nuremberg, Erlangen, Germany.
6
Affiliated Sixth People's Hospital Shanghai Jiao Tong University, Shanghai, P.R. China.

Abstract

AIMS:

To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).

METHODS:

Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS -ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.

RESULTS:

The mean ONH FI was 0.160 ± 0.010 for the HC group, 0.156 ± 0.017 for the MS-ON group, and 0.140 ± 0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5% compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43% vs 5%, p=0.01). Mean parafoveal FIs were 0.126 ± 0.007, 0.127 ± 0.010, and 0.129 ± 0.005 for the HC, MS-ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03% and 4.53% for ONH FI, and 1.65% and 3.55% for parafoveal FI.

CONCLUSIONS:

Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.

KEYWORDS:

Imaging; Optic Nerve; Retina

PMID:
24831719
PMCID:
PMC4598177
DOI:
10.1136/bjophthalmol-2013-304547
[Indexed for MEDLINE]
Free PMC Article

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