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Org Lett. 2014 Jun 6;16(11):2880-3. doi: 10.1021/ol500860v. Epub 2014 May 15.

Zoaramine, a zoanthamine-like alkaloid with a new skeleton.

Author information

1
University Institute of Bio-Organic Chemistry "Antonio González" and §Department de Chemical Engeneering and Pharmaceutical Technology, University of La Laguna , 38206 Tenerife, Spain.

Abstract

Chemical investigation of an Atlantic variety of Zoanthus sp. led to the isolation of two new metabolites, zoaramine and zoarenone. Their structures were deduced by the use of NMR spectroscopy and computational calculation of (1)H and (13)C chemical shifts. The core of these novel compounds resembles the structure of norzoanthamine alkaloids, and their isolation represents an important step toward a better understanding of the biogenetic origin of this group of antiosteoporotic molecules.

PMID:
24831410
DOI:
10.1021/ol500860v
[Indexed for MEDLINE]

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