Systemic sclerosis biomarkers discovered using mass-spectrometry-based proteomics: a systematic review

Biomarkers. 2014 Aug;19(5):345-55. doi: 10.3109/1354750X.2014.920046. Epub 2014 May 16.

Abstract

Context: Systemic sclerosis (SSc) is an autoimmune disease with incompletely known physiopathology. There is a great challenge to predict its course and therapeutic response using biomarkers.

Objective: To critically review proteomic biomarkers discovered from biological specimens from systemic sclerosis patients using mass spectrometry technologies.

Methods: Medline and Embase databases were searched in February 2014.

Results: Out of the 199 records retrieved, a total of 20 records were included, identifying 116 candidate proteomic biomarkers.

Conclusion: Research in SSc proteomic biomarkers should focus on biomarker validation, as there are valuable mass-spectrometry proteomics studies in the literature.

Keywords: Autoimmunity; biomarker validation; proteomic biomarkers; proteomics; systemic sclerosis.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Biomarkers / metabolism*
  • Humans
  • Mass Spectrometry / methods*
  • Proteome / metabolism*
  • Proteomics / methods*
  • Reproducibility of Results
  • Scleroderma, Systemic / diagnosis
  • Scleroderma, Systemic / metabolism*
  • Sensitivity and Specificity

Substances

  • Biomarkers
  • Proteome