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Biomed Res Int. 2014;2014:807635. doi: 10.1155/2014/807635. Epub 2014 Apr 16.

Hydrogen gas presents a promising therapeutic strategy for sepsis.

Author information

1
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, China ; Tianjin Institute of Anesthesiology, Tianjin 300052, China.

Abstract

Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF- κ B and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.

PMID:
24829918
PMCID:
PMC4009185
DOI:
10.1155/2014/807635
[Indexed for MEDLINE]
Free PMC Article

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