Format

Send to

Choose Destination
J Signal Transduct. 2014;2014:962962. doi: 10.1155/2014/962962. Epub 2014 Apr 16.

A Network Map of FGF-1/FGFR Signaling System.

Author information

1
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
2
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India ; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
3
Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
4
Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.
5
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Deregulation of FGF-1 signaling is not only implicated in tumorigenesis but also is associated with tumor invasion and metastasis. Given the biomedical significance of FGFs and the fact that individual FGFs have different roles in diverse physiological processes, the analysis of signaling pathways induced by the binding of specific FGFs to their cognate receptors demands more focused efforts. Currently, there are no resources in the public domain that facilitate the analysis of signaling pathways induced by individual FGFs in the FGF/FGFR signaling system. Towards this, we have developed a resource of signaling reactions triggered by FGF-1/FGFR system in various cell types/tissues. The pathway data and the reaction map are made available for download in different community standard data exchange formats through NetPath and NetSlim signaling pathway resources.

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center