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Hepat Mon. 2014 May 1;14(5):e17263. doi: 10.5812/hepatmon.17263. eCollection 2014 May.

Prevalence of hepatitis B virus seromarkers in young adults vaccinated at birth; impact on the epidemiology of hepatitis B infection in iran.

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Department of Pathology, Shariaty Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
Department of Immunology, Mazandaran University of Medical Sciences, Sari, IR Iran.
Pediatric Infectious Diseases Ward, Boali-Cina Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.
Provincial Center for Diseases Control and Prevention, Mazandaran University of Medical Sciences, Sari, IR Iran.
Department of Statistics, Mazandaran University of Medical Sciences, Sari, IR Iran.



The epidemiological impact and the duration of protection provided by infant hepatitis B (HB) vaccination are unknown.


This study was designed to determine the hepatitis B virus (HBV) infection seromarkers in young adults who have been vaccinated against HBV as the first group of Iranian neonates during 1993 and 1994.


We recruited 510 young adults with a history of complete HB vaccination at birth. HBV seromarkers (HB surface antigen (HBs Ag), antibody against HBs Ag (Anti-HBs), and antibody against HB core antigen (Anti-HBc) were measured using ELISA method. Anti-HBs titers ≥ 10 IU/L were considered protective and titers more than 300 IU/L were indicative of a natural boosting. Positive results for Anti-HBc and HBs Ag were considered as breakthrough infection and possible vaccine failure, respectively. The history of acute symptomatic clinical hepatitis was also investigated.


Anti-HBs seropositivity rate was detected in 224 of 510 [95% CI: 39-47] young adults. Breakthrough infection (positive sera for Anti-HBc without chronic infection) was observed in 18 [95% CI: 2.5-3.5] subjects. There were neither HBs Ag positive results nor symptomatic hepatitis cases.


The study results indicated that the neonatal HBV immunization induced a long-term protection against HBV and was very efficacious in reducing chronic HBV infection rate in vaccinated young adults in Iran.


HB Immunogenicity; Hepatitis B; Hepatitis B Vaccine; Iran

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