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Hepat Mon. 2014 Apr 14;14(4):e10330. doi: 10.5812/hepatmon.10330. eCollection 2014 Apr.

Protective Effect of Cornus mas Fruits Extract on Serum Biomarkers in CCl4-Induced Hepatotoxicity in Male Rats.

Author information

1
Middle East Liver Disease Center (MELD), Tehran, IR Iran.
2
Liver and Gastrointestinal Diseases Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran.
3
Baqiyatallah Research Center for Gastroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, IR Iran ; Drug Applied Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran.
4
Coordination Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran.

Abstract

BACKGROUND:

Nowadays attention to use herbs such as cornelian cherry (Cornus mas) is increasing, which contains high levels of antioxidants and anthocyanins. Cornus mas fruits have been used for gastrointestinal and excretory disorders for many years in traditional medicine, also may improve liver and kidney functions, and have protective effects such as anti-allergic, antidiabetic, antibacterial, antimicrobial, antihistamine and antimalarial properties.

OBJECTIVES:

The aim of this study was to investigate protective effects of Cornus mas fruits extract on serum biomarkers in CCl4-induced hepatotoxicity in male rats.

MATERIALS AND METHODS:

Hepatotoxicity was induced by administration of carbon tetrachloride (1 mL/kg i.p.) in 1:1 dilution with olive oil. To evaluate the effect of Cornus mas fruits extract on disease progression, serum marker enzymes, serum total protein and albumin and liver lipid peroxidation were determined in CCl4-induced hepatotoxicity.

RESULTS:

Oral administration of Cornus mas fruits extract to rats for 14 days provided a significant (P < 0.05) hepatoprotection by decreasing elevated serum level of enzymes, total serum protein, albumin and liver lipid peroxidation content.

CONCLUSIONS:

Cornus mas fruit extract effect may be due to including some antioxidant components, which caused membrane stabilizing and normalization of fluctuated biochemical profiles induced by CCl4 exposure. Our results validated the traditional use of Cornus mas in the treatment of liver disorders.

KEYWORDS:

Carbon Tetrachloride; Cornus mas; Hepatotoxicity; Lipid Peroxidation; Serum Biomarkers

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