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Biol Reprod. 2014 Jun;90(6):139. doi: 10.1095/biolreprod.114.118141. Epub 2014 May 14.

Maternal diabetes mellitus and the origin of non-communicable diseases in offspring: the role of epigenetics.

Author information

1
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P.R. China Reproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, Henan Province, P.R. China Reproductive Medicine Center, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
2
Reproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, Henan Province, P.R. China Reproductive Medicine Center, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
3
Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri.
4
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P.R. China sunqy@ioz.ac.cn.

Abstract

Offspring of diabetic mothers are susceptible to the onset of metabolic syndromes, such as type 2 diabetes and obesity at adulthood, and this trend can be inherited between generations. Genetics cannot fully explain how the noncommunicable disease in offspring of diabetic mothers is caused and inherited by the next generations. Many studies have confirmed that epigenetics may be crucial for the detrimental effects on offspring exposed to the hyperglycemic environment. Although the adverse effects on epigenetics in offspring of diabetic mothers may be the result of the poor intrauterine environment, epigenetic modifications in oocytes of diabetic mothers are also affected. Therefore, the present review is focused on the epigenetic alterations in oocytes and embryos of diabetic mothers. Furthermore, we also discuss initial mechanistic insight on maternal diabetes mellitus causing alterations of epigenetic modifications.

KEYWORDS:

embryo; epigenetics; maternal diabetes; offspring; oocyte

PMID:
24829025
DOI:
10.1095/biolreprod.114.118141
[Indexed for MEDLINE]

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