Complexity of metastasis-associated SDF-1 ligand signaling in breast cancer stem cells

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7503-4. doi: 10.1073/pnas.1405991111. Epub 2014 May 14.

Authors

Nicholas A Graham¹, Thomas G Graeber²

Affiliations

¹ Department of Molecular and Medical Pharmacology,Crump Institute for Molecular Imaging.
² Department of Molecular and Medical Pharmacology,Crump Institute for Molecular Imaging,University of California at Los Angeles Metabolomics and Proteomics Center,Jonsson Comprehensive Cancer Center, andCalifornia NanoSystems Institute, University of California, Los Angeles, CA 90095 tgraeber@mednet.ucla.edu.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Breast Neoplasms / genetics*
Chemokine CXCL12 / metabolism*
Feedback, Physiological / physiology*
Female
Humans
Neoplasm Metastasis / physiopathology*
Neoplastic Stem Cells / metabolism*
Receptors, CXCR4 / metabolism*
Signal Transduction / genetics*

Substances

CXCR4 protein, human
Chemokine CXCL12
Receptors, CXCR4

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