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J Gen Virol. 2014 Aug;95(Pt 8):1640-6. doi: 10.1099/vir.0.065425-0. Epub 2014 May 14.

NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery.

Author information

1
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
2
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK mariana.varela@glasgow.ac.uk massimo.palmarini@glasgow.ac.uk.
3
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, P.O. Box 7028, Uppsala SE-750 07, Sweden.
4
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise 'G. Caporale', Teramo, Italy.
5
Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany.

Abstract

Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.

PMID:
24828331
PMCID:
PMC4103064
DOI:
10.1099/vir.0.065425-0
[Indexed for MEDLINE]
Free PMC Article

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