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Tissue Antigens. 2014 Jun;83(6):375-81. doi: 10.1111/tan.12381.

MHC class I signaling: new functional perspectives for an old molecule.

Author information

1
Mattel Children's Hospital UCLA, Division of Pediatric Nephrology, Los Angeles, CA, USA.

Abstract

Donor-specific antibodies are associated with refractory rejection episodes and poor allograft outcomes in solid organ transplantation. Our understanding of antibody-mediated allograft injury is expanding beyond complement deposition. In fact, unique mechanisms of alloantibodies are advancing our knowledge about transplant vasculopathy and antibody-mediated rejection. These include direct effects on the endothelium, resulting in the recruitment of leukocytes, chemokine and cytokine production, and stimulation of innate and adaptive alloresponses. These effects will be the focus of the following review.

KEYWORDS:

alloantibodies; antibody-mediated rejection; complement; endothelium; human leukocyte antigen class I; therapy; transplant vasculopathy

PMID:
24828054
PMCID:
PMC4079505
DOI:
10.1111/tan.12381
[Indexed for MEDLINE]
Free PMC Article

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