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EMBO Rep. 2014 Jun;15(6):642-56. doi: 10.15252/embr.201438638. Epub 2014 May 12.

The Hippo signaling pathway in stem cell biology and cancer.

Author information

1
Department of Pharmacology and Moores Cancer Center, University of California, San Diego La Jolla, CA, USA.
2
Department of Pharmacology and Moores Cancer Center, University of California, San Diego La Jolla, CA, USA kuguan@ucsd.edu.

Abstract

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.

KEYWORDS:

Hippo pathway; YAP; cancer; regeneration; stem cell

PMID:
24825474
PMCID:
PMC4197875
DOI:
10.15252/embr.201438638
[Indexed for MEDLINE]
Free PMC Article

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