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Clin Neuropharmacol. 2014 May-Jun;37(3):84-7. doi: 10.1097/WNF.0000000000000031.

Ambroxol-induced focal epileptic seizure.

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Epilepsy Unit, Department of Neurological Sciences, "Sapienza" University of Rome, Rome, Italy.


It is well known that in epileptic patients some compounds and different drugs used for the treatment of comorbidities can facilitate or provoke seizures, this evidence regarding a wide spectrum of pharmacological categories. The potential facilitating factors usually include direct toxic effects or pharmacological interactions of either active ingredients or excipients. We report the case of a patient with drug-resistant epilepsy who experienced focal epileptic seizures, easily and constantly reproducible, after each administration of a cough syrup. This is, to our knowledge, the first electroencephalogram-documented case of focal epileptic seizures induced by cough syrup containing ambroxol as active ingredient.

[Indexed for MEDLINE]

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