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J Pharm Sci. 2014 Jul;103(7):1931-1944. doi: 10.1002/jps.24001. Epub 2014 May 13.

Silver nanoparticles: therapeutical uses, toxicity, and safety issues.

Author information

1
Department of Chemical Engineering Polytechnic School, University of Sao PauloBrazil.
2
Department of Chemical Engineering Polytechnic School, University of Sao PauloBrazil. Electronic address: mkrai123@rediffmail.com.
3
Department of Biotechnology SGB Amravati University Amravati444 602 Maharashtra India.
4
Department of Biotechnology SGB Amravati University Amravati444 602 Maharashtra India; Department of Biotechnology, Institute of Science Aurangabad 431004 Maharashtra India.
5
Department of Pharmacy, CIRPEB, University of Naples, "Federico II" and Istituto di Biostrutturee Bio immagini CNR Naples 80314 Italy.
6
Department of Experimental Medicine Division of Microbiology - II University of Naples Via De Crecchio 780138 Naples Italy.
7
Department of Biotechnology SGB Amravati University Amravati444 602 Maharashtra India; Department of BiologyUtah State UniversityLoganUtah84322.
8
Department of Biotechnology SGB Amravati University Amravati444 602 Maharashtra India. Electronic address: mahendrarai7@gmail.com.

Abstract

The promises of nanotechnology have been realized to deliver the greatest scientific and technological advances in several areas. The biocidal activity of Metal nanoparticles in general and silver nanoparticles (AgNPs) depends on several morphological and physicochemical characteristics of the particles. Many of the interactions of the AgNPs with the human body are still poorly understood; consequently, the most desirable characteristics for the AgNPs are not yet well established. Therefore, the development of nanoparticles with well-controlled morphological and physicochemical features for application in human body is still an active area of interdisciplinary research. Effects of the development of technology of nanostructured compounds seem to be so large and comprehensive that probably it will impact on all fields of science and technology. However, mechanisms of safety control in application, utilization, responsiveness, and disposal accumulation still need to be further studied in-depth to ensure that the advances provided by nanotechnology are real and liable to provide solid and consistent progress. This review aims to discuss AgNPs applied in biomedicine and as promising field for insertion and development of new compounds related to medical and pharmacy technology. The review also addresses drug delivery, toxicity issues, and the safety rules concerning biomedical applications of silver nanoparticles.

KEYWORDS:

antimicrobials; biomaterials; coating; drug delivery; nanotechnology; silver nanoparticles; synthesis; therapeutics; toxicity

PMID:
24824033
DOI:
10.1002/jps.24001
[Indexed for MEDLINE]

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