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Cancer Cell. 2014 May 12;25(5):563-73. doi: 10.1016/j.ccr.2014.03.015.

Endoplasmic reticulum stress in malignancy.

Author information

1
Department of Medicine, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
2
Department of Medicine, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK. Electronic address: sjm20@cam.ac.uk.

Abstract

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.

PMID:
24823636
DOI:
10.1016/j.ccr.2014.03.015
[Indexed for MEDLINE]
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