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Dev Cell. 2014 May 12;29(3):350-9. doi: 10.1016/j.devcel.2014.04.003.

A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.

Author information

1
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Department of Biochemistry and Molecular Biology, Drexel University, Philadelphia, PA 19102, USA.
2
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
3
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address: jonathan.chernoff@fccc.edu.

Abstract

Proper neural crest development and migration is critical during embryonic development, but the molecular mechanisms regulating this process remain incompletely understood. Here, we show that the protein kinase Erk, which plays a central role in a number of key developmental processes in vertebrates, is regulated in the developing neural crest by p21-activated protein kinase 1 (Pak1). Furthermore, we show that activated Erk signals by phosphorylating the transcription factor Gata6 on a conserved serine residue to promote neural crest migration and proper formation of craniofacial structures, pigment cells, and the outflow tract of the heart. Our data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.

PMID:
24823378
PMCID:
PMC4073496
DOI:
10.1016/j.devcel.2014.04.003
[Indexed for MEDLINE]
Free PMC Article

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