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Indian J Otolaryngol Head Neck Surg. 2014 Jun;66(2):131-4. doi: 10.1007/s12070-013-0623-0. Epub 2013 Feb 6.

The effect of Beta glucan on Cisplatin ototoxicity.

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Department of Otorhinolaryngology, Medical Faculty, Inonu University, Malatya, Turkey.
Department of Pharmacology, Istanbul Medeniyet University, Istanbul, Turkey.
Department of Otorhinolaryngology, Sutcu Imam University, Kahramanmaras, Turkey.
Department of Otorhinolaryngology, Medical Faculty, Istanbul Medeniyet University, Goztepe Hospital, Istanbul, Turkey.


This study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements. For the group B there were significant recovery in some frequencies. The observation of significant deterioration in terms of hearing in the group treated with cisplatin plus betaglucan may be suggested that depended on the increase of permeability and tissue conductance into the inner ear which may be caused by betaglucan. Further long-term follow-up studies by using different doses may clarify this matter.


Betaglucan; Cisplatin; Otoacoustic emissions; Ototoxicity

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