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J Venom Anim Toxins Incl Trop Dis. 2014 May 6;20:19. doi: 10.1186/1678-9199-20-19. eCollection 2014.

Septic arthritis: immunopathogenesis, experimental models and therapy.

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Departamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Distrito de Rubião Júnior, s/n, Botucatu, São Paulo State, Brazil.


Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included.


Mice; Septic arthritis; Staphylococcus aureus

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