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Eur J Prev Cardiol. 2015 Jul;22(7):882-9. doi: 10.1177/2047487314535682. Epub 2014 May 12.

Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease.

Author information

1
National Institute of Public Health, University of Southern Denmark Department of Cardiology, Holbaek Hospital, Denmark Department of Cardiology, Roskilde Hospital, Denmark tbh@regionsjaelland.dk.
2
National Institute of Public Health, University of Southern Denmark.
3
National Institute of Public Health, University of Southern Denmark Department of Cardiology, Holbaek Hospital, Denmark Department of Cardiology, Rigshospitalet, Denmark.
4
Department of Cardiology, Roskilde Hospital, Denmark.
5
Center of Research on Psychology in Somatic diseases (CoRPS), Tilburg University, Tilburg, The Netherlands.
6
Department of Medical Psychology, Innsbruck Medical University, Austria.
7
College of Health Sciences, University of Wisconsin-Milwaukee, University of Wisconsin School of Medicine and Public Health, and Aurora Cardiovascular Services, Aurora St. Luke's Medical Center, Milwaukee, WI, USA.

Abstract

BACKGROUND:

Patient health-related quality of life (HRQL) is an important health outcome with lower HRQL associated with adverse events in patients with ischaemic heart disease (IHD).

DESIGN:

Baseline health-related quality of life was investigated as a predictor of 5-year all-cause mortality and cardiac readmissions in Danish patients with IHD.

METHODS:

The international HeartQoL Project survey was designed to develop a core HRQL questionnaire for patients with IHD. Baseline scores on each of the 14 items ultimately included in the HeartQoL questionnaire were linked to Danish national health registries and hazard ratios for mortality and readmissions were estimated using Cox regression models.

RESULTS:

Among 938 eligible Danish patients with IHD, 662 (70.6%) participated in the international HeartQoL Project. During the 5-year follow-up, 83 patients died and 196 patients were readmitted. Adjusted analyses showed a significant linear association between all-cause mortality and both lower global HRQL (HR = 1.67, 95% CI: 1.26-2.23; p<0.001) and physical scores (HR=1.71, 1.33-2.21; p<0.001) and between readmission and both lower global (HR=1.73, 1.41-2.12; p < 0.001) and physical scores (HR = 1.63, 1.35-1.96; p < 0.001). A significant, but non-linear, effect was found for emotional HRQL score on outcomes.

CONCLUSION:

This study shows a significant and linear relationship between lower global and physical HRQL scores in patients with IHD and 5-year all-cause mortality and cardiac readmission.

KEYWORDS:

Health-related quality of life; angina; heart failure; ischaemic heart disease; long-term; mortality; myocardial infarction; readmission

PMID:
24821733
DOI:
10.1177/2047487314535682
[Indexed for MEDLINE]
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