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Macromol Biosci. 2014 Mar;14(3):314-9. doi: 10.1002/mabi.201300346. Epub 2013 Oct 30.

Generation of cellular micropatterns on a single-layered graphene film.

Author information

1
Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon, 305-701, Korea.

Abstract

Micropatterns of fibroblast and hippocampal neurons are generated on a single-layered graphene substrate. A large-area (1 cm × 1 cm) graphene film on Si/SiO2 is functionalized by surface-initiated ATRP of non-biofouling oligo(ethylene glycol) methacrylate, after grafting of the polymerization initiator bearing α-bromoisobutylate via photoreaction of the perfluorophenyl azide group. The microcontact printing-assisted spatio-selective reaction, after chemical activation of the terminal hydroxyl group of oligo(ethylene glycol) in the polymeric film, is utilized to generate the patterns of fibroblast and hippocampal neurons.

KEYWORDS:

aryl azide; cells; graphene; micropatterns; surface-initiated polymerization

PMID:
24821665
DOI:
10.1002/mabi.201300346
[Indexed for MEDLINE]
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