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Nat Rev Genet. 2014 Jul;15(7):469-79. doi: 10.1038/nrg3681. Epub 2014 May 13.

Insights into RNA structure and function from genome-wide studies.

Author information

1
1] Department of Molecular and Cell Biology, University of California, Berkeley. [2] Guardant Health, Inc., 2686 Middlefield Road, Redwood City, California 94063, USA. [3].
2
1] Department of Molecular and Cell Biology, University of California, Berkeley. [2].
3
1] Department of Molecular and Cell Biology, University of California, Berkeley. [2] Howard Hughes Medical Institute, University of California, Berkeley. [3] Department of Chemistry, University of California, Berkeley, California 94720, USA. [4] Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Abstract

A comprehensive understanding of RNA structure will provide fundamental insights into the cellular function of both coding and non-coding RNAs. Although many RNA structures have been analysed by traditional biophysical and biochemical methods, the low-throughput nature of these approaches has prevented investigation of the vast majority of cellular transcripts. Triggered by advances in sequencing technology, genome-wide approaches for probing the transcriptome are beginning to reveal how RNA structure affects each step of protein expression and RNA stability. In this Review, we discuss the emerging relationships between RNA structure and the regulation of gene expression.

PMID:
24821474
DOI:
10.1038/nrg3681
[Indexed for MEDLINE]
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