Format

Send to

Choose Destination
Curr Opin Immunol. 2014 Aug;29:62-8. doi: 10.1016/j.coi.2014.04.005. Epub 2014 May 13.

A systems biology approach to the effect of aging, immunosenescence and vaccine response.

Author information

1
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA. Electronic address: poland.gregory@mayo.edu.
2
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
3
Robert & Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.

Abstract

Aging can lead to immunosenescence, which dramatically impairs the hosts' ability to develop protective immune responses to vaccine antigens. Reasons for this are not well understood. This topic's importance is reflected in the increases in morbidity and mortality due to infectious diseases among elderly persons, a population growing in size globally, and the significantly lower adaptive immune responses generated to vaccines in this population. Here, we endeavor to summarize the existing data on the genetic and immunologic correlates of immunosenescence with respect to vaccine response. We cover how the application of systems biology can advance our understanding of vaccine immunosenescence, with a view toward how such information could lead to strategies to overcome the lower immunogenicity of vaccines in the elderly.

PMID:
24820347
PMCID:
PMC4119552
DOI:
10.1016/j.coi.2014.04.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center