Format

Send to

Choose Destination
EMBO Rep. 2014 Jul;15(7):758-65. doi: 10.15252/embr.201438869. Epub 2014 May 12.

Direct action of endocrine disrupting chemicals on human sperm.

Author information

1
Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Bonn, Germany.
2
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Denmark.
3
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Denmark nes@rh.dk timo.struenker@caesar.de.
4
Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Bonn, Germany nes@rh.dk timo.struenker@caesar.de.

Abstract

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

KEYWORDS:

Ca2+ signalling; CatSper; endocrine disrupting chemical; human sperm

PMID:
24820036
PMCID:
PMC4196979
DOI:
10.15252/embr.201438869
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center