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JAMA Intern Med. 2014 Jul;174(7):1077-84. doi: 10.1001/jamainternmed.2014.1582.

Resveratrol levels and all-cause mortality in older community-dwelling adults.

Author information

1
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
2
Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland.
3
New England Research Institute, Boston, Massachusetts.
4
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Laboratory, Food Technology Reference Net and Nutrition and Food Safety Research Institute (XaRTA and INSA ), Pharmacy School, University of Barcelona, Barcelona, Spain5Unit of Nutrit.
5
Geriatrics and Geriatric Emergency Department, Istituto Nazionale di Riposo e Cura per Anziani V.E.II.-Istituto di Ricovero e Cura a Carattere Scientifico (INRCA-IRCCS), Ancona, Italy.
6
Azienda Sanitaria, Florence, Italy.

Abstract

IMPORTANCE:

Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms.

OBJECTIVE:

To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans.

DESIGN:

Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study ("Aging in the Chianti Region"), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older.

EXPOSURES:

Twenty-four-hour urinary resveratrol metabolites.

MAIN OUTCOMES AND MEASURES:

Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.

RESULTS:

Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.

CONCLUSIONS AND RELEVANCE:

In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.

PMID:
24819981
PMCID:
PMC4346286
DOI:
10.1001/jamainternmed.2014.1582
[Indexed for MEDLINE]
Free PMC Article

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