Format

Send to

Choose Destination
J Eval Clin Pract. 2014 Dec;20(6):908-14. doi: 10.1111/jep.12147. Epub 2014 May 12.

How evidence-based medicine is failing due to biased trials and selective publication.

Author information

1
Te Korowai Whariki, Capital and Coast District Health Board, Porirua, New Zealand.

Abstract

Evidence-based medicine (EBM) was announced in the early 1990s as a 'new paradigm' for improving patient care. Yet there is currently little evidence that EBM has achieved its aim. Since its introduction, health care costs have increased while there remains a lack of high-quality evidence suggesting EBM has resulted in substantial population-level health gains. In this paper we suggest that EBM's potential for improving patients' health care has been thwarted by bias in the choice of hypotheses tested, manipulation of study design and selective publication. Evidence for these flaws is clearest in industry-funded studies. We argue EBM's indiscriminate acceptance of industry-generated 'evidence' is akin to letting politicians count their own votes. Given that most intervention studies are industry funded, this is a serious problem for the overall evidence base. Clinical decisions based on such evidence are likely to be misinformed, with patients given less effective, harmful or more expensive treatments. More investment in independent research is urgently required. Independent bodies, informed democratically, need to set research priorities. We also propose that evidence rating schemes are formally modified so research with conflict of interest bias is explicitly downgraded in value.

KEYWORDS:

evaluation; evidence-based medicine; health services research; mental health; philosophy

PMID:
24819404
DOI:
10.1111/jep.12147
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center