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J Magn Reson Imaging. 2015 Feb;41(2):296-313. doi: 10.1002/jmri.24648. Epub 2014 May 12.

Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging.

Author information

1
Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Abstract

Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor hemodynamics. DSC-MRI parameters can be helpful in many aspects, including tumor grading, prediction of treatment response, likelihood of malignant transformation, discrimination between tumor recurrence and radiation necrosis, and differentiation between true early progression and pseudoprogression. This review aims to provide a conceptual overview of the underlying principles of DSC-MRI of the brain for clinical neuroradiologists, scientists, or students wishing to improve their understanding of the technical aspects, pitfalls, and controversies of DSC perfusion MRI of the brain. Future consensus on image acquisition parameters and postprocessing of DSC-MRI will most likely allow this technique to be evaluated and used in high-quality multicenter studies and ultimately help guide clinical care.

KEYWORDS:

brain tumors; cerebral blood volume; echo planar imaging; gadolinium-based contrast agents; perfusion magnetic resonance imaging

PMID:
24817252
DOI:
10.1002/jmri.24648
[Indexed for MEDLINE]

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