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PLoS One. 2014 May 9;9(5):e96687. doi: 10.1371/journal.pone.0096687. eCollection 2014.

An integrated map of HIV-human protein complexes that facilitate viral infection.

Author information

1
Departments of Medicine and Bioengineering, University of California at San Diego, La Jolla, California, United States of America; IP&Science, Thomson Reuters Scientific Inc., Carlsbad, California, United States of America.
2
Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.
3
IP&Science, Thomson Reuters Scientific Inc., Carlsbad, California, United States of America.
4
The Salk Institute for Biological Studies, La Jolla, California, United States of America.
5
Departments of Medicine and Bioengineering, University of California at San Diego, La Jolla, California, United States of America.

Abstract

Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and can be used as a starting point for further functional analyses. We integrated this network with complementary datasets of protein function and interaction to nominate human protein complexes with likely roles in viral infection. Based on our approach we identified a global map of 40 HIV-human protein complexes with putative roles in HIV infection, some of which are involved in DNA replication and repair, transcription, translation, and cytoskeletal regulation. Targeted RNAi screens were used to validate several proteins and complexes for functional impact on viral infection. Thus, our HIV-human protein complex map provides a significant resource of potential HIV-host interactions for further study.

PMID:
24817247
PMCID:
PMC4016004
DOI:
10.1371/journal.pone.0096687
[Indexed for MEDLINE]
Free PMC Article
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