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J Sci Food Agric. 2015 Jan;95(2):401-8. doi: 10.1002/jsfa.6737. Epub 2014 Jun 24.

Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet.

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Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, No. 17 Tsinghua East Road, Haidian District, Beijing, 100083, China.



Rhizoma dioscorea, Lycium barbarum, Prunella vulgaris and hawthorn are well known in both traditional food and folk medicine. Each of these plants reportedly possesses beneficial effects in the treatment of diabetes. In this study an anti-diabetic health-promoting diet was formulated by mixing the herbs in a ratio of 6:4:2:3, and the anti-diabetic effect and underlying mechanism were elucidated in vivo.


Compared with the model control group, the formula, especially its ethanol extract (EF), could improve glucose intolerance and normalize the lipid profile. The mechanisms responsible for the amelioration of glucose and lipid metabolism in mice were an increase in peripheral and hepatic insulin sensitivity, a decrease in serum free fatty acid level, enhanced hepatic glucokinase activity and glycogen content and improved serum antioxidant activity. Hepatic histopathological examination also showed that EF administration markedly decreased fatty deposits in the liver of mice.


The results of the present study demonstrated that the prepared functional formula diet is a potent alternative as an anti-diabetic health-promoting diet.


Lycium barbarum; Prunella vulgaris; Rhizoma dioscorea; anti-diabetes; formula; hawthorn

[Indexed for MEDLINE]

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