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Cell Transplant. 2014;23(4-5):459-69. doi: 10.3727/096368914X678418.

Therapeutic potential of microRNA let-7: tumor suppression or impeding normal stemness.

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1
Graduate Institute of Immunology, China Medical University, Taichung, Taiwan.

Abstract

The first microRNA, let-7, and its family were discovered in Caenorhabditis elegans and are functionally conserved from worms to humans in the regulation of embryonic development and stemness. The let-7 family has been shown to have an essential role in stem cell differentiation and tumor-suppressive activity. Deregulating expression of let-7 is commonly reported in many human cancers. Emerging evidence has accumulated and suggests that reestablishment of let-7 in tumor cells is a valuable therapeutic strategy. However, findings reach beyond tumor therapeutics and may impinge on stemness and differentiation of stem cells. In this review, we discuss the role of let-7 in development and differentiation of normal adult stem/progenitor cells and offer a viewpoint of the association between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the application of let-7 are highlighted.

PMID:
24816444
DOI:
10.3727/096368914X678418
[Indexed for MEDLINE]

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