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Reumatol Clin. 2015 Mar-Apr;11(2):78-82. doi: 10.1016/j.reuma.2014.03.009. Epub 2014 May 10.

Anti-Müllerian hormone in reproductive age women with systemic lupus erythematosus.

[Article in English, Spanish]

Author information

1
Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.
2
Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México. Electronic address: drdavidvega@yahoo.com.mx.

Abstract

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune systemic and chronic disease. Fertility in SLE patients is considered normal; factors that have been associated in these patients with ovarian failure are: disease activity, autoantibodies, and the use of cytotoxic agents. The anti-Müllerian hormone (AMH) is a marker that helps to determine the follicular reserve.

OBJECTIVE:

Determinate the objective was to determine AMH levels in women of reproductive age with SLE.

MATERIAL AND METHODS:

We included 65 women with SLE classified according to the 1997 ACR criteria, 18- to 40-years old. We obtained demographic, clinical, obstetric, and gynecological characteristics as well as serum levels of AMH. We performed a bivariate analysis among patients with low ovarian reserve and those with normal ovarian reserve. We also performed a correlation analysis between activity and damage index and between the cumulative cyclophosphamide dose and AMH levels.

RESULTS:

We found a median of serum AMH in SLE patients of .61 ng/mL. The prevalence of low ovarian reserve in our study was 3.07%. We found a median MEX-SLEDAI score of 1 point and the median SLICC score was 2 points. Twenty-five patients (38.4%) had used cyclophosphamide and their cumulative average dose was 7.5 grams.

CONCLUSIONS:

We found a median of AMH of .61 ng/mL in our population. The prevalence of low ovarian reserve in SLE patients was 3.07%. We did not find a correlation between AMH levels, the use of cyclophosphamide, and disease activity.

KEYWORDS:

Anti-müllerian hormone; Ciclofosfamida; Cyclophosphamide; Hispanic americans; Hormona anti-mülleriana; Latinoamericanos; Lupus eritematoso sistémico; Systemic lupus erythematosus

PMID:
24815955
DOI:
10.1016/j.reuma.2014.03.009
[Indexed for MEDLINE]
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