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Asian Pac J Cancer Prev. 2014;15(7):3293-7.

Inhibitory effects of α-pinene on hepatoma carcinoma cell proliferation.

Author information

1
School of Basic Medicine and Guangdong Key Laboratory for Bioactive Drug Research, Guangdong Pharmaceutical University, Guangzhou, ChinaE-mail : cwq2187@163.com.

Abstract

BACKGROUND:

Pine needle oil from crude extract of pine needles has anti-tumor effects, but the effective component is not known.

METHODS:

In the present study, compounds from a steam distillation extract of pine needles were isolated and characterized. Alpha-pinene was identified as an active anti-proliferative compound on hepatoma carcinoma BEL-7402 cells using the MTT assay.

RESULTS:

Further experiments showed that α-pinene inhibited BEL-7402 cells by arresting cell growth in the G2/M phase of the cell cycle, downregulating Cdc25C mRNA and protein expression, and reducing cycle dependence on kinase 1(CDK1) activity.

CONCLUSION:

Taken together, these findings indicate that α-pinene may be useful as a potential anti-tumor drug.

PMID:
24815485
DOI:
10.7314/apjcp.2014.15.7.3293
[Indexed for MEDLINE]
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