Format

Send to

Choose Destination
Am J Med. 2014 Sep;127(9):888-90. doi: 10.1016/j.amjmed.2014.04.025. Epub 2014 May 9.

Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity.

Author information

1
Department of Health Sciences, University of Pavia, Pavia, Italy. Electronic address: enzo.emanuele@livingresearch.eu.
2
Department of Health Sciences, University of Pavia, Pavia, Italy.
3
Department of Physiology, University of Valencia and Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.
4
Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, Huesca, Spain; Instituto de Investigación Hospital 12 de Octubre ('i+12'), Madrid, Spain.
5
School of Doctorate Studies and Research, Universidad Europea Madrid, 28670 Villaviciosa de Odón, Madrid, Spain.

Abstract

BACKGROUND:

Skeletal muscles produce irisin. Growing controversy exists on the association between this myokine and chronic disease risk. On the basis of the potential protective effects that irisin could exert on both vascular function and skeletal muscle mass, we hypothesized that an elevated level of this molecule may contribute to successful aging.

METHODS:

Serum irisin levels were measured using enzyme-linked immunosorbent assay in disease-free centenarians, young healthy controls, and patients with precocious acute myocardial infarction.

RESULTS:

We found the highest levels of serum irisin in disease-free centenarians (35.3 ± 5.5 ng/mL) compared with young healthy controls (20.7 ± 6.3 ng/mL) and especially with young patients with acute myocardial infarction (15.1 ± 5.4 ng/mL).

CONCLUSIONS:

Our study demonstrates that healthy centenarians are characterized by increased serum irisin levels, whereas levels of this molecule were found to be significantly lower in young patients with myocardial infarction. Our findings may prompt further research into the role played by irisin not only in vascular disorders but also in life span modulation.

KEYWORDS:

Centenarians; Longevity; Myocardial infarction; Myokines

PMID:
24813865
DOI:
10.1016/j.amjmed.2014.04.025
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center