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Mol Cell. 2014 May 8;54(3):329-30. doi: 10.1016/j.molcel.2014.04.020.

Akt-ing up on SRPK1: oncogene or tumor suppressor?

Author information

1
Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: atoker@bidmc.harvard.edu.
2
Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: rchin1@bidmc.harvard.edu.

Abstract

In this issue of Molecular Cell, Wang et al. (2014) report that the splicing kinase SRPK1 can function as both an oncogene and a tumor suppressor by modulating the activation state of the protein kinase Akt. This is shown to be mediated by the ability of SRPK1 to bind to the Akt phosphatase PHLPP1.

PMID:
24813709
PMCID:
PMC4089875
DOI:
10.1016/j.molcel.2014.04.020
[Indexed for MEDLINE]
Free PMC Article

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