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Curr Opin Cell Biol. 2014 Jun;28:96-104. doi: 10.1016/j.ceb.2014.04.006. Epub 2014 Jun 2.

Unraveling architecture of the pluripotent genome.

Author information

1
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19103, USA. Electronic address: jcremins@seas.upenn.edu.

Abstract

Genomes are folded into sophisticated configurations that both shape, and are shaped by, a diverse range of nuclear functions. High-throughput variations of Chromosome-Conformation-Capture-based technologies now enable analysis of architecture at unprecedented resolution and scale. Here I discuss the complex structure-function relationship of the mammalian genome using the model system of embryonic stem cells, and the progression from pluripotency to terminal differentiation and back again.

PMID:
24813689
DOI:
10.1016/j.ceb.2014.04.006
[Indexed for MEDLINE]

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