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Acupunct Med. 2014 Aug;32(4):313-7. doi: 10.1136/acupmed-2014-010530. Epub 2014 May 9.

Plasma nesfatin-1 level in obese patients after acupuncture: a randomised controlled trial.

Author information

1
Department of Cardiology, The Affiliated Hospital of Medical College Qingdao University, Qingdao, China.
2
Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.
3
Department of Traditional Chinese Medicine, Qingdao Municipal Hospital, Qingdao, China.

Abstract

BACKGROUND:

Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity.

OBJECTIVE:

To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment.

METHODS:

64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days.

RESULTS:

Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05.

CONCLUSIONS:

Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.

KEYWORDS:

Acupuncture

PMID:
24813558
DOI:
10.1136/acupmed-2014-010530
[Indexed for MEDLINE]

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