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J Am Acad Dermatol. 2014 Aug;71(2):327-49. doi: 10.1016/j.jaad.2014.03.030. Epub 2014 May 9.

Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents.

Author information

1
Department of Dermatology, Seattle Children's Hospital, Seattle, Washington.
2
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
3
Department of Dermatology, New York University School of Medicine, New York, New York.
4
Department of Dermatology, University of California, San Francisco, California.
5
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
6
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
7
Department of Dermatology, Case Western University, Cleveland, Ohio.
8
Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, North Carolina.
9
Department of Dermatology, Oregon Health and Science University, Portland, Oregon.
10
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
11
Kaplan-Amonette Department of Dermatology, University of Tennessee Health Science Center, Memphis, Tennessee.
12
Private practice, Fairfax, Virginia.
13
University of San Diego, San Diego, California; Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California.
14
Center of Evidence-based Dermatology, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom.
15
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
16
National Eczema Association, San Rafael, California.
17
American Academy of Dermatology, Schaumburg, Illinois.
18
American Academy of Dermatology, Schaumburg, Illinois. Electronic address: wsmithbegolka@aad.org.

Abstract

Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the available evidence. In this third of 4 sections, treatment of atopic dermatitis with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option.

KEYWORDS:

atopic dermatitis; azathioprine; cyclosporin A; interferon gamma; methotrexate; mycophenolate mofetil; oral antihistamines; oral antimicrobials; oral steroids; photochemotherapy; phototherapy; systemic therapy

PMID:
24813298
PMCID:
PMC4410179
DOI:
10.1016/j.jaad.2014.03.030
[Indexed for MEDLINE]
Free PMC Article

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