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Mob Genet Elements. 2014 Jan 1;4(1):e28914. Epub 2014 Apr 23.

A case of horizontal gene transfer from Wolbachia to Aedes albopictus C6/36 cell line.

Author information

1
Department of Pathogen Biology; Nanjing Medical University; Nanjing, Jiangsu People's Republic of China.
2
Department of Pathogen Biology; Nanjing Medical University; Nanjing, Jiangsu People's Republic of China ; State Key Laboratory of Surveillance and Detection for Medical Vectors; Xiamen Entry-Exit Inspection and Quarantine Bureau; Xiamen, Fujian People's Republic of China.

Abstract

Horizontal gene transfer plays an essential role in evolution and ecological adaptation, yet this phenomenon has remained controversial, particularly where it occurs between prokaryotes and eukaryotes. There are a handful of reported examples of horizontal gene transfer occurring between prokaryotes and eukaryotes in the literature, with most of these documented cases pertaining to invertebrates and endosymbionts. However, the vast majority of these horizontally transferred genes were either eventually excluded or rapidly became nonfunctional in the recipient genome. In this study, we report the discovery of a horizontal gene transfer from the endosymbiont Wolbachia in the C6/36 cell line derived from the mosquito Aedes albopictus. Moreover, we report that this horizontally transferred gene displayed high transcription level. This finding and the results of further experimentation strongly suggest this gene is functional and has been expressed and translated into a protein in the mosquito host cells.

KEYWORDS:

Aedes Albopictus; C6/36 cell line; Wolbachia; endosymbiont; horizontal gene transfer; mosquito

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