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Science. 2014 May 9;344(6184):1241062. doi: 10.1126/science.1241062.

Sound strategies for hearing restoration.

Author information

1
Department of Otolaryngology, F. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Hearing loss is the most common sensory deficit in humans, with some estimates suggesting up to 300 million affected individuals worldwide. Both environmental and genetic factors contribute to hearing loss and can cause death of sensory cells and neurons. Because these cells do not regenerate, the damage tends to accumulate, leading to profound deafness. Several biological strategies to restore auditory function are currently under investigation. Owing to the success of cochlear implants, which offer partial recovery of auditory function for some profoundly deaf patients, potential biological therapies must extend hearing restoration to include greater auditory acuity and larger patient populations. Here, we review the latest gene, stem-cell, and molecular strategies for restoring auditory function in animal models and the prospects for translating these approaches into viable clinical therapies.

PMID:
24812404
PMCID:
PMC4148779
DOI:
10.1126/science.1241062
[Indexed for MEDLINE]
Free PMC Article

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