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Small GTPases. 2014;5:e28579. doi: 10.4161/sgtp.28579. Epub 2014 May 8.

Rho GTPases, oxidation, and cell redox control.

Author information

1
Department of Biochemistry and Biophysics; University of North Carolina; Chapel Hill, NC USA.
2
Department of Pharmacology; University of North Carolina; Chapel Hill, NC USA.
3
Department of Pharmacology; University of North Carolina; Chapel Hill, NC USA; Department of Radiation Oncology, University of North Carolina; Chapel Hill, NC USA; Lineberger Comprehensive Cancer Center; University of North Carolina; Chapel Hill, NC USA.
4
Department of Biochemistry and Biophysics; University of North Carolina; Chapel Hill, NC USA; Lineberger Comprehensive Cancer Center; University of North Carolina; Chapel Hill, NC USA.

Abstract

While numerous studies support regulation of Ras GTPases by reactive oxygen and nitrogen species, the Rho subfamily has received considerably less attention. Over the last few years, increasing evidence is emerging that supports the redox sensitivity of Rho GTPases. Moreover, as Rho GTPases regulate the cellular redox state by controlling enzymes that generate and convert reactive oxygen and nitrogen species, redox feedback loops likely exist. Here, we provide an overview of cellular oxidants, Rho GTPases, and their inter-dependence.

KEYWORDS:

2-electron oxidants; Ras GTPases; cysteine oxidation; free radicals; post-translational modifications; reactive nitrogen species; reactive oxygen species

PMID:
24809833
PMCID:
PMC4114927
DOI:
10.4161/sgtp.28579
[Indexed for MEDLINE]
Free PMC Article

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